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Subsequent experiments in a transgenic mouse line demonstrated that these effects were dependent on SIRT3

10.1016/j.ejphar.2012.01.010 Summary Keywords acetaminophen, phytic acid, iron, SIRT -1, CYP2E1 , liver Citation Hassan HM, Abdel-Halim NHM, El-Shenbaby I, Helmy MA, Hammad MO, Habotta OA, El Nashar EM, Alghamdi MA, Aldahhan RA, Al-Khater KM, Almohaywi B and Farrag EAE (2024) Phytic acid attenuates acetaminophen-induced hepatotoxicity via modulating iron-mediated oxidative stress and SIRT-1 expression in mice